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Starting dosage: 20 mg every 6 hours; adjust dosage to individual patient needs. 35% of reviewers reported a positive effect, while 49% reported a negative. 9 out of 10 from a total of 393 ratings on Drugs. Although they work more slowly than antacids they provide relief for a longer period of time. Pepcid and Prilosec are available over-the-counter ( OTC) and in generic form. Pepcid and Prilosec are available over-the-counter ( OTC) and in generic form Pepcid (famotidine) is an oral drug that belongs to a family of drugs called H2 blockers. Pepcid AC is used to relieve heartburn symptoms associated with indigestion PEPCID® is a histamine-2 blocker with the active ingredient famotidine. Males may also have swollen breast tissue. Omeprazole has an average rating of 4. Some long-term side effects can be mild, such as: 1. Pepcid (famotidine) Prescription and OTC Famotidine is an acid-suppressing agent that may be used to treat a wide range of gastric-acid-related disorders including gastric ulcers, heartburn, and GERD. These drugs effectively treat about ½ the patients with GERD. Alot of people including myself, the prescription for Prilosec is cheaper than OTC but yes, same ingredients, same dose. Studies have shown it is best to take OTC famotidine 1 hour before an evening meal to help prevent heartburn and indigestion in the evening and during bedtime which may interfere with your sleep PEPCID® is a histamine-2 blocker with the active ingredient famotidine. Good for you for being a wise consumer shopper! As a prescription, it is available in 400mg, 600mg, and 800mg dosages Regardless, prescription drugs are highly purified and contain more omega-3s than OTC supplements. Common side effects of Pepcid include: constipation, diarrhea, fatigue, dizziness, weakness, mood changes, headache, insomnia,. 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